燒傷再生醫(yī)學(xué)預(yù)防控制燒傷創(chuàng)面感染技術(shù)的臨床研究

摘要： 目的對(duì)比觀察燒傷再生醫(yī)療技術(shù)(MEBT/MEB0)與燒傷外科治療技術(shù)(SD-Ag和/或植皮)在預(yù)防控制燒傷創(chuàng)面感染的臨床效果。方法將60例符合入選標(biāo)準(zhǔn)的大面積重度燒傷患者隨機(jī)分為研究組(MEBO組,30例)和對(duì)照組(SD-Ag組,30例),患者入院后分別按照燒傷再生醫(yī)療技術(shù)或燒傷外科治療技術(shù)的治療原則,進(jìn)行規(guī)范的系統(tǒng)治療及創(chuàng)面處理。觀察、記錄兩組患者的抗生素平均使用天數(shù)、抗生素二次使用率、侵襲性感染發(fā)生率、不同深度燒傷創(chuàng)面的愈合時(shí)間和手術(shù)植皮率。結(jié)果經(jīng)過(guò)治療,兩組患者的創(chuàng)面均實(shí)現(xiàn)了愈合,研究組平均愈合時(shí)間34.9 d±8.6 d,對(duì)照組平均愈合時(shí)間39.4 d±9.1 d?？股仄骄褂锰鞌?shù):研究組7.5d,對(duì)照組15.5d。抗生素二次使用情況:研究組4例(13.3%),對(duì)照組9例(30.0%)。創(chuàng)面侵襲性感染情況:研究組4例(13.3%),對(duì)照組20例(66.7%)。植皮手術(shù):研究組3例(10.0%),對(duì)照組20例(66.7%)。經(jīng)t檢驗(yàn)或X~2檢驗(yàn),兩組間各指標(biāo)相比均有顯著性差異(P<0.05)。結(jié)論燒傷再生醫(yī)療技術(shù)治療大面積重度燒傷能夠有效預(yù)防控制創(chuàng)面感染、減少抗生素使用、促進(jìn)創(chuàng)面愈合和降低手術(shù)植皮率,收到了較好的預(yù)防控制燒傷創(chuàng)面感染的臨床效果,值得臨床推廣應(yīng)用和進(jìn)一步深入研究。
Objective To observe and compare the clinical efficacy of Bums Regenerative Medicine(MEBT/ MEBO) and Burns Surgical Treatment(SD-Ag and/or skin-grafting) in preventing and controlling wound infection of burns. Methods A total of 60 hospitalized patients with extensive major burns were enrolled into the study and divided into the study group(MEBO group,30 cases) or the control group(SD-Ag group,30 cases) randomly.After the admission,all the cases were given standard systemic treatment and wound management following the treatment principle of either Burns Regenerative Medicine or Burns Surgical Treatment.The following indexes including the average administration duration of antibiotics, the second-time administration rate of antibiotics,the incurrence of invasive infection,and the healing time of wounds with various depths as well as the rate of skin grafting of the two groups were observed and recorded.Results After the treatment,the wounds of the two groups all healed.The average healing time of the study group was 34.9±8.6 d;that of the control group was 39.4±9.1 d.As for the average administration duration of antibiotics,it was 7.5 d for the study group and 15.5 d for the control group.The second-time administration rate of antibiotics was 4(13.3%) in the study group and 9(30.0%) in the control group.Four cases(13.3%) in the test group developed invasive wound infection while the number for the control group was 20(66.1%).Three cases(10%) in the study group and 20 cases in the control group(66.7%) accepted skin grafting.Based on t test andχ~2 test,all the indexes of the two groups were significantly different(P<0.05 ).Conclusion MEBT/MEBO approach to treating extensive major burns can obtain great clinical efficacy in terms of effectively preventing and controlling the occurrence of wound infection,reducing the administration of antibiotics, promoting wound healing and reducing the incurrence of skin grafting.It deserves to be promoted for wide application and further research.