濕潤燒傷膏在燒傷創(chuàng)面治療中的作用

摘要： 燒傷治療一直是燒傷領域中的一大難題。燒傷創(chuàng)面的局部治療要求早期清創(chuàng),并為創(chuàng)面提供一個適宜的環(huán)境刺激上皮形成和細胞的分化。早在30年前,燒傷的標準化治療方案就已經(jīng)形成,包括早期切痂及韌厚皮移植,但治療效果不盡人意。為了改善愈合后的皮膚質量,尤其是減少增生性瘢痕的產(chǎn)生,人們仍需探索新的治療方法。筆者對Kilpauk醫(yī)學院醫(yī)院的燒傷患者進行了創(chuàng)面愈合評價,包括100名經(jīng)濕潤燒傷膏(MEBO)治療的患者及100名經(jīng)磺胺嘧啶銀軟膏治療的患者,并對比分析了兩組患者創(chuàng)面的愈合效果。結果顯示,MEBO在深Ⅱ度淺型及深Ⅱ度深型燒傷患者的治療中取得了成功。MEBO可在創(chuàng)面形成一種具有抗炎作用的生理性濕潤環(huán)境,并為創(chuàng)面提供了一種營養(yǎng)基質,這種營養(yǎng)基質能清除創(chuàng)面焦痂并促進創(chuàng)面上皮再生。本前瞻性研究旨在評價MEBO在Ⅱ度燒傷中的應用效果。2010年8月至2011年5月期間,100名經(jīng)MEBO治療的Ⅱ度燒傷患者同另100名使用磺胺嘧啶銀軟膏治療的Ⅱ度燒傷患者在清創(chuàng)效果,抗炎效果,愈合效果,瘢痕形成及色素沉著方面進行了對比,結果發(fā)現(xiàn)經(jīng)過MEBO治愈的創(chuàng)面,皮膚顏色及瘢痕形成均優(yōu)于磺胺嘧啶銀組。
Management of burns remains one of the greatest challenges in bum care.Local management of a bum wound requires early wound debridement and an optimum environment to stimulate epithelialisation and cellular proliferation. Protocol was developed as early as 30 years ago for the management of burns that includes early excision and SSG coverage. The results were not perfect.The quality of healed skin as well as the prominence of hypertrophic scar needs to explore the novel approaches.Wound healing assessment was made in bum wounds in 100 patients treated with MEBO cream and in 100 patients with Silver Sulpha Diazine Cream at the Kilpauk Medical College Hospital,Burns Unit.The comparative analysis is presented to assess the wound healing pattern in both the groups.Moist exposed bum ointment has been used with success in the management of deep superficial partial thickness and deep partial thickness burns in our department.The MEBO cream creates a physiological moist environment over the wound inducing an anti-inflammatory effect.It provides a nutritive base for the wound and debrides the wound eschar and expedites wound epithelialisation.The purpose of this study was to prospectively evaluate the outcome of the use of MEBO for second degree bums.Between August 2010 to May 2011 period 100 patients with second degree bums underwent MEBO cream application and were compared with 100 patients who had silver sulphadiazine cream.The result was analysed for the nature of wound debridement,reduction of inflammation, healing pattern,scar and pigmentation,MEBO provides excellent skin pigmentation and minimal visible scar.