依達(dá)拉奉對(duì)重型彌漫性軸索損傷神經(jīng)功能恢復(fù)的影響

摘要： 目的探討依達(dá)拉奉對(duì)患者彌漫性軸索損傷(diffuse axonal injury,DAI)的促醒作用及對(duì)神經(jīng)功能恢復(fù)的影響。方法將彌漫性軸索損傷患者70例隨機(jī)分為2組,對(duì)照組和治療組各35例。對(duì)照組給予止血、脫水、促醒、營(yíng)養(yǎng)神經(jīng)、維持水電解質(zhì)平衡、營(yíng)養(yǎng)支持、控制血糖和防治相關(guān)并發(fā)癥等常規(guī)治療。治療組在常規(guī)治療的基礎(chǔ)上加用依達(dá)拉奉30mg靜脈滴注,2次/d,共14d。2組患者均于治療前,治療7、14d后分別進(jìn)行神經(jīng)功能缺損程度評(píng)定和臨床療效評(píng)定。2組患者均隨訪3個(gè)月,分別觀察比較2組清醒率、清醒時(shí)間。結(jié)果與對(duì)照組相比,治療組神經(jīng)功能程度評(píng)分、清醒率及清醒時(shí)間明顯優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論依達(dá)拉奉能夠縮短彌漫性軸索損傷患者的昏迷時(shí)間,提高清醒率,促進(jìn)神經(jīng)功能康復(fù)。
Objective To explore the awakening effect and neurologic functional rehabilitation of edaravone on patients with diffuse axonal injury(DAI).Methods Seventy patients with DAI were randomly divided into treatment group and control group with 35 cases in each group.The control group was given hemostasis,dehydvation,awaking neurotrophic,maintaining water and electrdyte blance, netritional support,control of blood sugar and prevention of complications and other conventional treatment.The treatment group was administered edaravone,30mg of which was intravenously infused 2 times per day for 14 days,in addition to the conventional therapy of the control group.Before treatment, and 7 days,14 days after treatment,the degree of neural function defect and clinical efficacy evaluation were performed in patients of two groups.All the patients were followed up for 3 months,and the awake rate and awake time were compared.Results Neural function defect score,awakening rate and awakening time of the treatment group were better than those in control group and there was statistically significant difference between the two groups(P <0.05 ).Conclusion Edaravone can shorten coma time,increase awakening rate and improve neural function rehabilitation of the patients with diffuse axonal injury.