低分子肝素聯(lián)合不同劑量阿司匹林治療急性腦梗死的療效和安全性比較

摘要： 目的觀察相同劑量低分子肝素聯(lián)合不同劑量阿司匹林腸溶片治療急性腦梗死的臨床療效和安全性。方法將急性腦梗死患者80例隨機(jī)分為對(duì)照組和治療組各40例。2組低分子肝素用量相同,5 000U腹部皮下注射,2次/d,連用2周。對(duì)照組阿司匹林100mg口服,1次/d,連用2周,治療組阿司匹林300mg口服,1次/d,連用2周。2周后觀察2組治療前后神經(jīng)功能缺損評(píng)分、臨床療效及凝血功能變化。結(jié)果與對(duì)照組相比,治療組治療后神經(jīng)功能缺損評(píng)分明顯降低,臨床有效率顯著提高,差異有統(tǒng)計(jì)學(xué)意義(P<0.05),而治療前后凝血功能差異無統(tǒng)汁學(xué)意義(P>0.05)。結(jié)論在腦梗死急性期,低分子肝素同等條件下,阿司匹林腸溶片300mg/d臨床療效優(yōu)于100mg/d。
Objective To observe the clinical effect and safety of same dose of low molecular weight heparin in combination with different doses of enteric - coated aspirin tablet in the treatment of acute cerebral infarction.Methods Eighty patients with acute cerebral infarction were randomly divided into control group and treatment group with 40 cases in each group.The same dose of low molecular weight heparin was used in two groups,5 000 U injected subcutaneously,twice daily for 2 weeks.In control group,aspirin 100 mg was given orally once a day for 2 weeks.In treatment group,aspirin 300 mg was given orally once a day for 2 weeks.Neurological deficit score,clinical efficacy and coagulation function changes were observed before and 2 weeks after treatment.Results Compared with the control group,neurological deficit score in treatment group was significantly lower and clinical efficiency significantly increased,the difference was statistically significant(P<0.05),and there was no significant difference in coagulation function before and after treatment(P > 0.05).Conclusion With the same dose of low molecular weight heparin,enteric -coated aspirin tablets at 300 mg/d is superior to 100mg/d used in improving clinical efficacy of acute cerebral infarction.