再生療法治療泛發(fā)性皮膚與皮下組織缺損的臨床研究

摘要： 目的進(jìn)一步探討原位再生療法和美寶濕潤燒傷膏(MEBT/MEBO)治療泛發(fā)性皮膚與皮下組織缺損的臨床療效。方法選擇2004年3月至2008年6月,4年間符合臨床研究標(biāo)準(zhǔn)的我科體表組織缺損住院患者56例。全程應(yīng)用原位再生療法和美寶濕潤燒傷膏(MEBT/MEBO)治療,通過光鏡觀察缺損部位愈合過程中近遠(yuǎn)期病理變化,缺損部位愈質(zhì)量,愈合時(shí)間。結(jié)果 56例患者因原發(fā)病導(dǎo)致窒息死亡1例(占1.67%),未愈出院5例(占8.93%),治愈50例(占89.29%)。平均愈合時(shí)間(62.26±12.59)d。治愈病例基本恢復(fù)了原有的外形和功能,無明顯增生性瘢痕出現(xiàn),達(dá)到了原位再生目的。結(jié)論各種因素造成的多部位深度皮膚與皮下組織缺損,應(yīng)用原位再生療法治療,均可達(dá)到原位再生修復(fù)的目的 ,可恢復(fù)良好的外形與功能。
Objective Further explore the clinical therapeutic effect of in situ regenerative therapy (MEBT/MEBO) on the treatment of generalized cutaneous and hypodermal tissue defects.Methods 56 in hospital patients with body surface tissue defects meeting the clinical study criteria in our department from March 2004 to June 2008 were enlisted to be treated with in situ regenerative therapy all along,main statistical indicators included degree of tissue defect,therapeutic method,healing time and short - term and long - term observations.Results Among 56 patients,one(1.67%) died of suffocation due to the primary disease,5 (8.93%) left hospital without healing,50(89.29%) were cured with an average healing time of 62.26±12.59 d,among which 4(7.14%) were treated in combination with a little postage stamp graft.Cured patients mainly recovered original appearance and functions without apparent hypertrophic scarring,achieved regeneration in situ.Conclusion Multiple sites of deep cutaneous and hypodermal tissue defects due to various causes were treated with in situ regenerative therapy and generally achieved regenerative reparation in situ with the recovery of good appearance and functions.